Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
PTCH1–RET
(HGNC:9585, HGNC:9967)
MONDO:0006509
(MONDO:0006509)
 weak weak weak weak weak
RET–TRIM27
(HGNC:9967, HGNC:9975)
MONDO:0005075
(MONDO:0005075)
 moderate weak weak moderate weak
PML–RARA
(HGNC:9113, HGNC:9864)
MONDO:0012883
(MONDO:0012883)
 strong strong strong strong strong
PRKACA–PRKACB
(HGNC:9380, HGNC:9381)
strong weak moderate strong weak
PAX8–RET
(HGNC:8622, HGNC:9967)
MONDO:0005034
(MONDO:0005034)
 weak weak weak weak weak
PDGFRB–PRKG2
(HGNC:8804, HGNC:9416)
MONDO:0016586
(MONDO:0016586)
 strong strong moderate strong weak
PAX8–PPARG
(HGNC:8622, HGNC:9236)
MONDO:0005089
(MONDO:0005089)
 strong moderate moderate strong weak
PDGFRA–PDGFRB
(HGNC:8803, HGNC:8804)
chronic eosinophilic leukemia
(MONDO_0015687)
 moderate strong moderate strong weak
NUP98–RARG
(HGNC:8068, HGNC:9866)
MONDO:0018874
(MONDO:0018874)
 strong strong moderate strong weak
PAX3–PAX7
(HGNC:8617, HGNC:8621)
MONDO:0005212
(MONDO:0005212)
 weak weak weak weak weak
NUP98–KDM5A
(HGNC:8068, HGNC:9886)
MONDO:0018872
(MONDO:0018872)
 strong weak moderate strong weak
NUP98–PSIP1
(HGNC:8068, HGNC:9527)
MONDO:0018874
(MONDO:0018874)
 strong moderate strong strong strong
NUP98–PRRX1
(HGNC:8068, HGNC:9142)
MONDO:0005059
(MONDO:0005059)
 strong moderate moderate strong weak
NTRK3–RET
(HGNC:8033, HGNC:9967)
MONDO:0005034
(MONDO:0005034)
 moderate moderate weak strong weak
NTRK1–NTRK3
(HGNC:8031, HGNC:8033)
weak weak weak weak weak
NUP98–RAP1GDS1
(HGNC:8068, HGNC:9859)
T-cell acute lymphoblastic leukemia
(MONDO_0004963)
 strong weak moderate strong weak
NTRK2–NTRK3
(HGNC:8032, HGNC:8033)
weak weak weak weak weak
NTRK1–NTRK2
(HGNC:8031, HGNC:8032)
colorectal carcinoma
(MONDO_0024331)
 weak weak weak weak weak
NR4A3–PGR
(HGNC:7982, HGNC:8910)
epithelioid leiomyosarcoma
(MONDO_0003356)
 strong weak moderate strong weak
NRG1–NRG2
(HGNC:7997, HGNC:7998)
MONDO:0005233
(MONDO:0005233)
 strong strong strong strong weak
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