Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
IQCG–NUP98
(HGNC:25251, HGNC:8068)
leukemia
(MONDO_0005059)
 weak weak weak weak weak
DAZAP1–MEF2D
(HGNC:2683, HGNC:6997)
MONDO:0004967
(MONDO:0004967)
 strong weak weak moderate weak
DAXX–ATRX
(HGNC:2681, HGNC:886)
gastrointestinal stromal tumor
(MONDO_0011719)
 weak weak weak weak weak
POU2AF3–EWSR1
(HGNC:26978, HGNC:3508)
MONDO:0005089
(MONDO:0005089)
 strong weak moderate strong weak
CTSC–RAB38
(HGNC:2528, HGNC:9776)
MONDO:0007154
(MONDO:0007154)
 moderate moderate moderate moderate weak
CLIP2–MET
(HGNC:2586, HGNC:7029)
MONDO:0016729
(MONDO:0016729)
 moderate weak weak moderate weak
CYP2E1–MTG1
(HGNC:2631, HGNC:32159)
strong weak weak strong weak
CYP11B1–CYP11B2
(HGNC:2591, HGNC:2592)
congenital adrenal hyperplasia
(MONDO_0018479)
 weak weak weak weak weak
BCORL1–JAZF1
(HGNC:25657, HGNC:28917)
MONDO:0007886
(MONDO:0007886)
 strong moderate moderate strong weak
CTNNB1–PLAG1
(HGNC:2514, HGNC:9045)
MONDO:0008401
(MONDO:0008401)
 strong weak moderate strong weak
KIAA1217–RET
(HGNC:25428, HGNC:9967)
non-small cell lung carcinoma
(MONDO_0005233)
 strong strong moderate strong weak
CUX1–NUTM1
(HGNC:2557, HGNC:29919)
MONDO:0004947
(MONDO:0004947)
 moderate weak moderate moderate weak
KNL1–KMT2A
(HGNC:24054, HGNC:7132)
acute myeloid leukemia with minimal differentiation
(MONDO_0005223)
 moderate weak moderate moderate weak
GREB1–NCOA2
(HGNC:24885, HGNC:7669)
MONDO:0005089
(MONDO:0005089)
 strong weak moderate strong weak
SH3PXD2A–HTRA1
(HGNC:23664, HGNC:9476)
MONDO:0002546
(MONDO:0002546)
 strong strong moderate strong weak
GREB1–CTNNB1
(HGNC:24885, HGNC:2514)
MONDO:0003311
(MONDO:0003311)
 strong moderate moderate strong weak
WWTR1–FOSB
(HGNC:24042, HGNC:3797)
MONDO:0003945
(MONDO:0003945)
 moderate weak weak strong weak
ACKR3–HMGA2
(HGNC:23692, HGNC:5009)
MONDO:0005106
(MONDO:0005106)
 moderate weak weak strong weak
CREB3L2–FUS
(HGNC:23720, HGNC:4010)
low grade fibromyxoid sarcoma
(MONDO_0006272)
 strong weak moderate strong weak
CREM–FUS
(HGNC:2352, HGNC:4010)
weak weak weak moderate weak
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