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Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
KAT6B–OPN1LW
(HGNC:17582, HGNC:9936)
weak weak weak weak weak
PLA2G15–NFATC3
(HGNC:17163, HGNC:7777)
leukemia
(MONDO_0005059)
 strong weak strong moderate weak
STARD3–PPP1R1B
(HGNC:17579, HGNC:9287)
MONDO:0001056
(MONDO:0001056)
 strong strong moderate strong weak
ERC1–RET
(HGNC:17072, HGNC:9967)
MONDO:0005075
(MONDO:0005075)
 strong strong moderate moderate weak
ARHGAP26–CLDN18
(HGNC:17073, HGNC:2039)
MONDO:0004992
(MONDO:0004992)
 strong strong moderate strong weak
MEAF6–SUZ12
(HGNC:25674, HGNC:17101)
MONDO:0006745
(MONDO:0006745)
 moderate weak weak moderate weak
CD74–NRG1
(HGNC:1697, HGNC:7997)
lung adenocarcinoma
(MONDO_0005061)
 strong strong moderate strong weak
ERC1–FGFR2
(HGNC:17072, HGNC:3689)
MONDO:0005061
(MONDO:0005061)
 strong moderate moderate moderate weak
HNRNPUL1–MEF2D
(HGNC:17011, HGNC:6997)
MONDO:0004967
(MONDO:0004967)
 strong strong strong moderate weak
ZMYND11–MBTD1
(HGNC:16966, HGNC:19866)
childhood acute myeloid leukemia
(MONDO_0004996)
 strong weak moderate moderate weak
SEC31A–ALK
(HGNC:17052, HGNC:427)
inflammatory myofibroblastic tumor
(MONDO_0015798)
 strong strong moderate strong weak
CEP43–FGFR1
(HGNC:17012, HGNC:3688)
acquired polycythemia vera
(MONDO_0009891)
 moderate weak moderate moderate weak
MLLT11–KMT2A
(HGNC:16997, HGNC:7132)
MONDO:0005059
(MONDO:0005059)
 strong weak moderate strong weak
CD28–CTLA4
(HGNC:1653, HGNC:2505)
MONDO:0015758
(MONDO:0015758)
 strong strong moderate strong weak
FBXW7–NOTCH1
(HGNC:16712, HGNC:7881)
T-cell acute lymphoblastic leukemia
(MONDO_0004963)
 weak weak weak weak weak
CD47–MET
(HGNC:1682, HGNC:7029)
non-small cell lung carcinoma
(MONDO_0005233)
 strong strong moderate strong weak
ETV6–ACSL6
(HGNC:3495, HGNC:16496)
myeloproliferative neoplasm
(MONDO_0020076)
 strong moderate strong moderate weak
CARD11–PIK3R3
(HGNC:16393, HGNC:8981)
hematopoietic and lymphoid system neoplasm
(MONDO_0002334)
 strong strong moderate strong weak
SLC45A2–AMACR
(HGNC:16472, HGNC:451)
liver cancer
(MONDO_0002691)
 strong strong moderate moderate weak
TRIM33–RET
(HGNC:16290, HGNC:9967)
MONDO:0005192
(MONDO:0005192)
 moderate moderate weak moderate weak
Showing 281–300 of 512