Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
PICALM–MLLT10
(HGNC:15514, HGNC:16063)
MONDO:0004967
(MONDO:0004967)
 strong strong strong strong moderate
CCND3–IGH
(HGNC:1585, HGNC:5477)
plasma cell myeloma
(MONDO_0009693)
 moderate weak weak strong weak
CBFA2T3–NFIA
(HGNC:1537, HGNC:7784)
MONDO:0017858
(MONDO:0017858)
 weak weak weak moderate weak
CCND1–FGFR1
(HGNC:1582, HGNC:3688)
MONDO:0007254
(MONDO:0007254)
 strong weak moderate strong weak
PICALM–KMT2A
(HGNC:15514, HGNC:7132)
MONDO:0018874
(MONDO:0018874)
 moderate weak moderate moderate weak
TP63–DUSP22
(HGNC:15979, HGNC:16077)
MONDO:0020325
(MONDO:0020325)
 weak weak weak weak weak
CCND1–PTH
(HGNC:1582, HGNC:9606)
benign neoplasm
(MONDO_0005165)
 strong weak weak strong weak
SEPTIN6–KMT2A
(HGNC:15848, HGNC:7132)
acute lymphoblastic leukemia
(MONDO_0004967)
 strong moderate moderate strong weak
CCND1–IGH
(HGNC:1582, HGNC:5477)
mantle cell lymphoma
(MONDO_0018876)
 strong moderate moderate strong weak
NCKIPSD–KMT2A
(HGNC:15486, HGNC:7132)
MONDO:0004967
(MONDO:0004967)
 moderate weak moderate strong weak
KLF15–EWSR1
(HGNC:14536, HGNC:3508)
malignant myoepithelioma
(MONDO_0003158)
 strong moderate moderate strong weak
RBM15–MAL
(HGNC:14959, HGNC:6817)
MONDO:0018872
(MONDO:0018872)
 strong weak moderate strong weak
CARS1–ALK
(HGNC:1493, HGNC:427)
MONDO:0015798
(MONDO:0015798)
 strong strong moderate strong weak
CBL–KMT2A
(HGNC:1541, HGNC:7132)
acute myeloid leukemia
(MONDO_0018874)
 moderate weak moderate strong weak
CBFB–MYH11
(HGNC:1539, HGNC:7569)
MONDO:0018871
(MONDO:0018871)
 strong weak moderate strong strong
CBFA2T3–GLIS2
(HGNC:1537, HGNC:29450)
acute megakaryoblastic leukemia
(MONDO_0018872)
 strong strong strong strong weak
KIF13A–RET
(HGNC:14566, HGNC:9967)
MONDO:0005233
(MONDO:0005233)
 strong strong moderate strong weak
BCAS3–BCAS4
(HGNC:14347, HGNC:14367)
MONDO:0007254
(MONDO:0007254)
 moderate weak weak moderate weak
MRTFA–RBM15
(HGNC:14334, HGNC:14959)
MONDO:0018872
(MONDO:0018872)
 strong moderate moderate strong strong
CRLF2–IGH
(HGNC:14281, HGNC:5477)
MONDO:0004947
(MONDO:0004947)
 weak weak weak moderate weak
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