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Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
CRLF2–P2RY8
(HGNC:14281, HGNC:15524)
acute lymphoblastic leukemia
(MONDO_0004967)
 strong strong strong strong moderate
NSD1–NUP98
(HGNC:14234, HGNC:8068)
MONDO:0004996
(MONDO:0004996)
 strong strong strong strong moderate
ARHGEF12–KMT2A
(HGNC:14193, HGNC:7132)
MONDO:0018874
(MONDO:0018874)
 strong weak moderate moderate weak
MGA–NUTM1
(HGNC:14010, HGNC:29919)
nut midline carcinoma
(MONDO_0005563)
 strong weak moderate strong weak
PRDM16–MECOM
(HGNC:14000, HGNC:3498)
MONDO:0018874
(MONDO:0018874)
 moderate weak moderate moderate weak
CPSF6–RARG
(HGNC:13871, HGNC:9866)
MONDO:0018874
(MONDO:0018874)
 strong strong moderate strong weak
MXD4–NUTM1
(HGNC:13906, HGNC:29919)
nut midline carcinoma
(MONDO_0005563)
 moderate weak moderate strong weak
MAML1–NR1D1
(HGNC:13632, HGNC:7962)
soft tissue neoplasm
(MONDO_0006424)
 moderate weak weak strong weak
TRAF3IP2–FYN
(HGNC:1343, HGNC:4037)
MONDO:0004977
(MONDO:0004977)
 strong strong moderate strong weak
BCL11A–IGH
(HGNC:13221, HGNC:5477)
MONDO:0000432
(MONDO:0000432)
 moderate weak moderate strong weak
BCL11B–TLX3
(HGNC:13222, HGNC:13532)
MONDO:0004963
(MONDO:0004963)
 strong moderate moderate strong weak
BRD4–LEUTX
(HGNC:13575, HGNC:31953)
MONDO:0004540
(MONDO:0004540)
 strong moderate moderate strong weak
BRD4–NUTM1
(HGNC:13575, HGNC:29919)
nut midline carcinoma
(MONDO_0005563)
 strong moderate strong strong weak
BRD4–NUTM2A
(HGNC:13575, HGNC:23438)
nut midline carcinoma
(MONDO_0005563)
 strong moderate moderate strong weak
PATZ1–EWSR1
(HGNC:13071, HGNC:3508)
MONDO:0958300
(MONDO:0958300)
 strong moderate moderate strong weak
EML4–NPM1
(HGNC:1316, HGNC:7910)
weak weak weak weak weak
EML4–KIF5B
(HGNC:1316, HGNC:6324)
weak weak weak weak weak
EML4–MET
(HGNC:1316, HGNC:7029)
lung cancer
(MONDO_0008903)
 strong strong moderate strong weak
KAT6A–NCOA2
(HGNC:13013, HGNC:7669)
acute biphenotypic leukemia
(MONDO_0020322)
 strong moderate moderate strong weak
KAT6A–OPN1LW
(HGNC:13013, HGNC:9936)
MONDO:0020076
(MONDO:0020076)
 weak weak weak weak weak
Showing 341–360 of 512