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Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
KAT6A–EP300
(HGNC:13013, HGNC:3373)
MONDO:0018908
(MONDO:0018908)
 strong weak moderate strong weak
ZMYM2–FGFR1
(HGNC:12989, HGNC:3688)
MONDO:0013296
(MONDO:0013296)
 strong strong strong strong weak
KAT6A–LEUTX
(HGNC:13013, HGNC:31953)
MONDO:0018874
(MONDO:0018874)
 moderate weak weak moderate weak
ZBTB16–RARA
(HGNC:12930, HGNC:9864)
MONDO:0012883
(MONDO:0012883)
 strong moderate moderate strong moderate
ZBTB16–PML
(HGNC:12930, HGNC:9113)
MONDO:0012883
(MONDO:0012883)
 weak weak weak weak weak
YY1–EWSR1
(HGNC:12856, HGNC:3508)
MONDO:0005065
(MONDO:0005065)
 strong weak weak moderate weak
YWHAE–JAZF1
(HGNC:12851, HGNC:28917)
MONDO:0006745
(MONDO:0006745)
 moderate moderate moderate moderate weak
YWHAE–BCOR
(HGNC:12851, HGNC:20893)
clear cell sarcoma of kidney
(MONDO_0005006)
 weak weak weak weak weak
YWHAE–NUTM2B
(HGNC:12851, HGNC:23445)
endometrioid stromal sarcoma
(MONDO_0006745)
 strong moderate moderate strong weak
WT1–EWSR1
(HGNC:12796, HGNC:3508)
MONDO:0019373
(MONDO:0019373)
 strong moderate moderate strong weak
NSD3–NUP98
(HGNC:12767, HGNC:8068)
MONDO:0018874
(MONDO:0018874)
 strong moderate strong strong weak
NSD3–NUTM1
(HGNC:12767, HGNC:29919)
lung neoplasm
(MONDO_0021117)
 moderate moderate moderate strong weak
VCL–ALK
(HGNC:12665, HGNC:427)
kidney medullary carcinoma
(MONDO_0006260)
 strong strong moderate strong weak
NSD2–IGH
(HGNC:12766, HGNC:5477)
monoclonal gammopathy of uncertain significance
(MONDO_0004225)
 strong moderate strong strong moderate
VAV1–MYO1F
(HGNC:12657, HGNC:7600)
MONDO:0004992
(MONDO:0004992)
 strong strong moderate moderate weak
USP8–PDGFRA
(HGNC:12631, HGNC:8803)
MONDO:0015798
(MONDO:0015798)
 strong moderate weak strong weak
USP6–MYH9
(HGNC:12629, HGNC:7579)
MONDO:0004187
(MONDO:0004187)
 strong weak moderate strong weak
USP2–KMT2A
(HGNC:12618, HGNC:7132)
MONDO:0004996
(MONDO:0004996)
 moderate moderate moderate strong weak
USP6–COL1A1
(HGNC:12629, HGNC:2197)
MONDO:0018815
(MONDO:0018815)
 strong weak moderate strong weak
UBE2L3–KRAS
(HGNC:12488, HGNC:6407)
prostate cancer
(MONDO_0008315)
 moderate weak weak moderate weak
Showing 361–380 of 512