Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
NR4A2–NR4A3
(HGNC:7981, HGNC:7982)
MONDO:0004965
(MONDO:0004965)
 weak weak weak weak weak
NPM1–RARA
(HGNC:7910, HGNC:9864)
aleukemic leukemia cutis
(MONDO_0003729)
 strong strong moderate strong weak
ABL1–NUP214
(HGNC:76, HGNC:8064)
MONDO:0004963
(MONDO:0004963)
 strong strong moderate strong weak
NCOA2–PAX3
(HGNC:7669, HGNC:8617)
MONDO:0020664
(MONDO:0020664)
 moderate moderate moderate strong weak
NCOA4–RET
(HGNC:7671, HGNC:9967)
MONDO:0005075
(MONDO:0005075)
 strong strong moderate strong weak
MYC–BCL2
(HGNC:7553, HGNC:990)
MONDO:0000873
(MONDO:0000873)
 strong strong strong strong weak
MYBL1–NFIB
(HGNC:7547, HGNC:7785)
adenoid cystic carcinoma
(MONDO_0004971)
 strong moderate moderate strong weak
NCOA1–PRRX1
(HGNC:7668, HGNC:9142)
MONDO:0002616
(MONDO:0002616)
 strong weak moderate strong weak
MYO5A–NTRK3
(HGNC:7602, HGNC:8033)
MONDO:0016729
(MONDO:0016729)
 strong strong moderate strong weak
MYB–NFIB
(HGNC:7545, HGNC:7785)
adenoid cystic carcinoma
(MONDO_0004971)
 strong strong moderate strong weak
AFF1–MLLT3
(HGNC:7135, HGNC:7136)
MONDO:0004967
(MONDO:0004967)
 weak weak weak weak weak
KMT2A–SEPTIN5
(HGNC:7132, HGNC:9164)
MONDO:0004967
(MONDO:0004967)
 strong weak moderate strong weak
KMT2A–OPN1LW
(HGNC:7132, HGNC:9936)
MONDO:0020311
(MONDO:0020311)
 weak weak weak weak weak
MYB–MYBL1
(HGNC:7545, HGNC:7547)
adenoid cystic carcinoma
(MONDO_0004971)
 strong moderate moderate strong weak
KMT2A–SEPTIN2
(HGNC:7132, HGNC:7729)
acute myeloid leukemia
(MONDO_0018874)
 moderate weak moderate moderate weak
KMT2A–MLLT6
(HGNC:7132, HGNC:7138)
acute myeloid leukemia
(MONDO_0018874)
 moderate weak weak moderate weak
KMT2A–NUP98
(HGNC:7132, HGNC:8068)
MONDO:0018874
(MONDO:0018874)
 moderate moderate moderate strong weak
KMT2A–RARA
(HGNC:7132, HGNC:9864)
MONDO:0018874
(MONDO:0018874)
 moderate weak moderate moderate weak
KMT2A–MYC
(HGNC:7132, HGNC:7553)
MONDO:0007243
(MONDO:0007243)
 weak weak weak weak weak
KMT2A–SEPTIN9
(HGNC:7132, HGNC:7323)
MONDO:0018881
(MONDO:0018881)
 strong moderate strong moderate weak
Showing 21–40 of 512