Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
TMPRSS2–ETV1
(HGNC:11876, HGNC:3490)
prostate cancer
(MONDO_0008315)
 weak weak weak weak weak
TIMP3–ALK
(HGNC:11822, HGNC:427)
MONDO:0005103
(MONDO:0005103)
 strong strong moderate strong weak
THBS1–ADGRF5
(HGNC:11785, HGNC:19030)
strong weak moderate strong weak
TGFBR3–OGA
(HGNC:11774, HGNC:7056)
MONDO:0002142
(MONDO:0002142)
 weak weak weak weak weak
TFG–ALK
(HGNC:11758, HGNC:427)
MONDO:0004817
(MONDO:0004817)
 moderate strong moderate strong weak
TFE3–PRCC
(HGNC:11752, HGNC:9343)
MONDO:0017884
(MONDO:0017884)
 strong strong moderate strong moderate
TFE3–IGFBP7
(HGNC:11752, HGNC:5476)
neoplasm with perivascular epithelioid cell differentiation
(MONDO_0006359)
 strong moderate moderate strong weak
TFG–MET
(HGNC:11758, HGNC:7029)
spindle cell sarcoma
(MONDO_0002927)
 strong strong moderate strong weak
TFE3–RBM10
(HGNC:11752, HGNC:9896)
MONDO:0005086
(MONDO:0005086)
 strong weak moderate strong weak
TFE3–PHF1
(HGNC:11752, HGNC:8919)
ossifying fibromyxoid tumor
(MONDO_0006330)
 strong weak moderate strong weak
TFE3–YAP1
(HGNC:11752, HGNC:16262)
epithelioid hemangioendothelioma
(MONDO_0015523)
 strong weak moderate strong weak
TFE3–EWSR1
(HGNC:11752, HGNC:3508)
MONDO:0011655
(MONDO:0011655)
 strong weak weak strong weak
TFE3–TFEB
(HGNC:11752, HGNC:11753)
renal cell carcinoma
(MONDO_0005086)
 weak weak weak weak weak
MED15–TFE3
(HGNC:14248, HGNC:11752)
MONDO:0006397
(MONDO:0006397)
 strong weak moderate strong weak
TFE3–ASPSCR1
(HGNC:11752, HGNC:13825)
alveolar soft part sarcoma
(MONDO_0011655)
 strong moderate moderate strong weak
TFCP2–EWSR1
(HGNC:11748, HGNC:3508)
rhabdomyosarcoma
(MONDO_0005212)
 moderate weak moderate strong weak
TERT–LPCAT1
(HGNC:11730, HGNC:25718)
MONDO:0020634
(MONDO:0020634)
 strong moderate strong strong weak
TFCP2–FUS
(HGNC:11748, HGNC:4010)
MONDO:0005212
(MONDO:0005212)
 strong moderate strong strong weak
TCF7L2–VTI1A
(HGNC:11641, HGNC:17792)
colorectal adenocarcinoma
(MONDO_0005008)
 strong moderate moderate weak weak
TCF3–ZNF384
(HGNC:11633, HGNC:11955)
MONDO:0018874
(MONDO:0018874)
 strong strong strong strong weak
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