Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
TCF3–PBX1
(HGNC:11633, HGNC:8632)
precursor B-cell acute lymphoblastic leukemia
(MONDO_0020511)
 strong moderate strong strong strong
TAF15–NR4A3
(HGNC:11547, HGNC:7982)
extraskeletal myxoid chondrosarcoma
(MONDO_0012825)
 strong weak weak strong weak
TCF3–HLF
(HGNC:11633, HGNC:4977)
MONDO:0004967
(MONDO:0004967)
 strong moderate strong strong moderate
TACC3–FGFR3
(HGNC:11524, HGNC:3690)
MONDO:0021042
(MONDO:0021042)
 strong strong moderate strong weak
TAF15–EWSR1
(HGNC:11547, HGNC:3508)
MONDO:0012817
(MONDO:0012817)
 weak weak weak weak weak
TAF15–ZNF384
(HGNC:11547, HGNC:11955)
MONDO:0004967
(MONDO:0004967)
 moderate weak moderate strong weak
EPCAM–MSH2
(HGNC:11529, HGNC:7325)
hereditary nonpolyposis colon cancer
(MONDO_0018630)
 strong strong moderate strong weak
TACC2–FGFR2
(HGNC:11523, HGNC:3689)
MONDO:0005192
(MONDO:0005192)
 strong strong moderate strong weak
TACC1–FGFR1
(HGNC:11522, HGNC:3688)
extraventricular neurocytoma
(MONDO_0016727)
 strong strong moderate strong weak
SYN2–PPARG
(HGNC:11495, HGNC:9236)
MONDO:0004965
(MONDO:0004965)
 moderate weak moderate moderate weak
ITK–SYK
(HGNC:6171, HGNC:11491)
primary cutaneous peripheral T-cell lymphoma not otherwise specified
(MONDO_0019476)
 strong strong moderate strong weak
STAT6–NAB2
(HGNC:11368, HGNC:7627)
solitary fibrous tumor
(MONDO_0016238)
 strong weak moderate strong weak
STAT5B–RARA
(HGNC:11367, HGNC:9864)
MONDO:0012883
(MONDO:0012883)
 moderate moderate moderate strong weak
STRN–ALK
(HGNC:11424, HGNC:427)
MONDO:0015075
(MONDO:0015075)
 strong strong moderate strong weak
SS18–POU5F1
(HGNC:11340, HGNC:9221)
MONDO:0018078
(MONDO:0018078)
 strong weak moderate moderate weak
STAT3–JAK2
(HGNC:11364, HGNC:6192)
MONDO:0850112
(MONDO:0850112)
 strong moderate moderate strong weak
SS18–MEF2C
(HGNC:11340, HGNC:6996)
MONDO:0021357
(MONDO:0021357)
 strong weak moderate strong weak
STAT5B–PML
(HGNC:11367, HGNC:9113)
MONDO:0012883
(MONDO:0012883)
 weak weak weak weak weak
SS18–EWSR1
(HGNC:11340, HGNC:3508)
MONDO:0010434
(MONDO:0010434)
 weak weak weak weak weak
SSX2–EWSR1
(HGNC:11336, HGNC:3508)
moderate moderate moderate strong weak
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