Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
SSX2–SS18
(HGNC:11336, HGNC:11340)
synovial sarcoma
(MONDO_0010434)
 strong weak moderate strong weak
SSX1–SS18
(HGNC:11335, HGNC:11340)
MONDO:0010434
(MONDO:0010434)
 strong weak strong strong moderate
ABI1–KMT2A
(HGNC:11320, HGNC:7132)
MONDO:0018874
(MONDO:0018874)
 moderate weak moderate moderate weak
SSX1–SSX2
(HGNC:11335, HGNC:11336)
MONDO:0010434
(MONDO:0010434)
 weak weak weak weak weak
SQSTM1–NTRK3
(HGNC:11280, HGNC:8033)
spindle cell neoplasm
(MONDO_0020664)
 moderate strong moderate strong weak
SRF–NCOA2
(HGNC:11291, HGNC:7669)
MONDO:0002581
(MONDO:0002581)
 moderate weak weak strong weak
SRF–RELA
(HGNC:11291, HGNC:9955)
MONDO:0016824
(MONDO:0016824)
 strong moderate moderate strong weak
SLC3A2–NRG1
(HGNC:11026, HGNC:7997)
lung cancer
(MONDO_0008903)
 moderate moderate weak moderate weak
BRAF–RET
(HGNC:1097, HGNC:9967)
thyroid gland papillary carcinoma
(MONDO_0005075)
 weak weak weak weak weak
BRCA1–BRCA2
(HGNC:1100, HGNC:1101)
MONDO:0008315
(MONDO:0008315)
 weak weak weak weak weak
SQSTM1–NTRK2
(HGNC:11280, HGNC:8032)
strong strong weak strong weak
BRD3–NUTM1
(HGNC:1104, HGNC:29919)
nut midline carcinoma
(MONDO_0005563)
 strong moderate strong strong weak
SQSTM1–NTRK1
(HGNC:11280, HGNC:8031)
MONDO:0005233
(MONDO:0005233)
 strong strong moderate strong weak
BRAF–CLIP2
(HGNC:1097, HGNC:2586)
MONDO:0005070
(MONDO:0005070)
 moderate weak moderate moderate weak
SQSTM1–ALK
(HGNC:11280, HGNC:427)
MONDO:0002989
(MONDO:0002989)
 strong strong moderate strong weak
SLC8A1–ALK
(HGNC:11068, HGNC:427)
MONDO:0005061
(MONDO:0005061)
 moderate moderate moderate moderate weak
BRD3–BRD4
(HGNC:1104, HGNC:13575)
weak weak weak weak weak
BRAF–TTYH3
(HGNC:1097, HGNC:22222)
MONDO:0018177
(MONDO:0018177)
 strong strong moderate strong weak
BRAF–SND1
(HGNC:1097, HGNC:30646)
MONDO:0850353
(MONDO:0850353)
 strong strong moderate moderate weak
BRAF–RAF1
(HGNC:1097, HGNC:9829)
pleomorphic xanthoastrocytoma
(MONDO_0016690)
 weak weak weak weak weak
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