Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
PMEL–TAL1
(HGNC:10880, HGNC:11556)
MONDO:0015758
(MONDO:0015758)
 strong moderate strong strong moderate
BCR–JAK2
(HGNC:1014, HGNC:6192)
MONDO:0011996
(MONDO:0011996)
 strong strong moderate strong weak
SET–NUP214
(HGNC:10760, HGNC:8064)
MONDO:0020321
(MONDO:0020321)
 strong strong strong strong moderate
SFPQ–TFE3
(HGNC:10774, HGNC:11752)
neoplasm with perivascular epithelioid cell differentiation
(MONDO_0006359)
 strong strong moderate strong weak
SH3GL1–KMT2A
(HGNC:10830, HGNC:7132)
MONDO:0018874
(MONDO:0018874)
 strong weak moderate strong weak
RUNX2–IRF2BP2
(HGNC:10472, HGNC:21729)
MONDO:0005096
(MONDO:0005096)
 strong weak moderate strong weak
ROS1–EML4
(HGNC:10261, HGNC:1316)
lung adenocarcinoma
(MONDO_0005061)
 weak weak weak weak weak
RUNX1–KMT2A
(HGNC:10471, HGNC:7132)
leukemia
(MONDO_0005059)
 strong moderate moderate strong weak
RUNX1–CBFB
(HGNC:10471, HGNC:1539)
MONDO:0010643
(MONDO:0010643)
 moderate weak moderate moderate weak
ROS1–SLC34A2
(HGNC:10261, HGNC:11020)
gastric cancer
(MONDO_0001056)
 strong strong moderate strong weak
ROS1–TPR
(HGNC:10261, HGNC:12017)
MONDO:0858940
(MONDO:0858940)
 strong moderate moderate strong weak
RUNX1–USP42
(HGNC:10471, HGNC:20068)
acute myeloid leukemia
(MONDO_0018874)
 strong weak moderate strong weak
RUNX1–CBFA2T3
(HGNC:10471, HGNC:1537)
leukemia
(MONDO_0005059)
 strong moderate moderate strong weak
RUNX1–RUNX1T1
(HGNC:10471, HGNC:1535)
MONDO:0018874
(MONDO:0018874)
 strong moderate moderate strong strong
RUNX1–PRDM16
(HGNC:10471, HGNC:14000)
MONDO:0018874
(MONDO:0018874)
 strong moderate strong moderate weak
CLIP1–LTK
(HGNC:10461, HGNC:6721)
lung cancer
(MONDO_0008903)
 strong strong moderate strong weak
RPS6KB1–VMP1
(HGNC:10436, HGNC:29559)
esophageal adenocarcinoma
(MONDO_0005028)
 strong moderate strong moderate weak
RREB1–MRTFB
(HGNC:10449, HGNC:29819)
strong weak moderate strong weak
ROS1–LDLR
(HGNC:10261, HGNC:6547)
lung adenocarcinoma
(MONDO_0005061)
 moderate strong moderate strong weak
ROS1–TFG
(HGNC:10261, HGNC:11758)
MONDO:0016642
(MONDO:0016642)
 strong strong moderate strong weak
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