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Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
KMT2A–AFDN
(HGNC:7132, HGNC:7137)
MONDO:0005223
(MONDO:0005223)
 strong weak strong strong moderate
LMNA–NTRK1
(HGNC:6636, HGNC:8031)
myopericytoma
(MONDO_0017349)
 strong strong moderate strong weak
MALT1–BCL10
(HGNC:6819, HGNC:989)
MALT lymphoma
(MONDO_0007650)
 weak weak weak weak weak
KMT2A–MLLT3
(HGNC:7132, HGNC:7136)
MONDO:0018874
(MONDO:0018874)
 strong strong moderate strong moderate
KMT2A–AFF1
(HGNC:7132, HGNC:7135)
MONDO:0004967
(MONDO:0004967)
 strong moderate strong strong strong
KMT2A–MLLT1
(HGNC:7132, HGNC:7134)
leukemia
(MONDO_0005059)
 strong moderate moderate strong weak
LASP1–KMT2A
(HGNC:6513, HGNC:7132)
MONDO:0010643
(MONDO:0010643)
 moderate weak moderate strong weak
MET–NTRK1
(HGNC:7029, HGNC:8031)
MONDO:0006033
(MONDO:0006033)
 moderate moderate moderate strong weak
MLF1–NPM1
(HGNC:7125, HGNC:7910)
myelodysplastic syndrome
(MONDO_0018881)
 strong strong moderate strong strong
MET–PTPRZ1
(HGNC:7029, HGNC:9685)
MONDO:0018177
(MONDO:0018177)
 strong strong strong moderate weak
MEIS1–NCOA2
(HGNC:7000, HGNC:7669)
adenosarcoma
(MONDO_0005636)
 strong weak moderate strong weak
MEF2D–NTRK1
(HGNC:6997, HGNC:8031)
MONDO:0005212
(MONDO:0005212)
 moderate moderate weak moderate weak
MBD1–PDGFRB
(HGNC:6916, HGNC:8804)
weak weak weak weak weak
MEF2D–NCOA2
(HGNC:6997, HGNC:7669)
smooth muscle tumor
(MONDO_0006975)
 strong weak moderate strong weak
MAP3K8–ABLIM1
(HGNC:6860, HGNC:78)
MONDO:0005065
(MONDO:0005065)
 moderate weak moderate moderate weak
BIRC3–MALT1
(HGNC:591, HGNC:6819)
MONDO:0007650
(MONDO:0007650)
 strong moderate strong strong weak
KIF5B–MET
(HGNC:6324, HGNC:7029)
lung adenocarcinoma
(MONDO_0005061)
 strong strong moderate strong weak
KIF5B–RET
(HGNC:6324, HGNC:9967)
MONDO:0005061
(MONDO:0005061)
 strong strong moderate strong weak
KDR–PDGFRA
(HGNC:6307, HGNC:8803)
MONDO:0016695
(MONDO:0016695)
 moderate strong moderate moderate weak
JAK2–MBD1
(HGNC:6192, HGNC:6916)
precursor B-cell acute lymphoblastic leukemia
(MONDO_0020511)
 weak weak weak weak weak
Showing 41–60 of 512