Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
JAK2–KMT2A
(HGNC:6192, HGNC:7132)
MONDO:0004967
(MONDO:0004967)
 strong strong moderate strong weak
INSL3–MYCL
(HGNC:6086, HGNC:7555)
small cell lung carcinoma
(MONDO_0008433)
 strong moderate moderate strong weak
ALK–KIF5B
(HGNC:427, HGNC:6324)
MONDO:0008903
(MONDO:0008903)
 strong strong moderate strong weak
IGH–MYC
(HGNC:5477, HGNC:7553)
Burkitt lymphoma
(MONDO_0007243)
 strong moderate strong strong moderate
IGH–BCL3
(HGNC:5477, HGNC:998)
MONDO:0004948
(MONDO:0004948)
 strong moderate strong strong weak
IGH–BCL2
(HGNC:5477, HGNC:990)
MONDO:0018908
(MONDO:0018908)
 strong moderate moderate strong strong
IGH–PAX5
(HGNC:5477, HGNC:8619)
MONDO:0004095
(MONDO:0004095)
 strong weak moderate strong weak
IGH–IGL
(HGNC:5477, HGNC:5853)
MONDO:0018908
(MONDO:0018908)
 strong strong moderate strong weak
IGH–MALT1
(HGNC:5477, HGNC:6819)
primary cutaneous marginal zone B-cell lymphoma
(MONDO_0015813)
 strong weak moderate strong weak
IGH–IGK
(HGNC:5477, HGNC:5715)
MONDO:0018874
(MONDO:0018874)
 weak weak weak weak weak
HOXD11–NUP98
(HGNC:5134, HGNC:8068)
acute myelomonocytic leukemia M4
(MONDO_0018871)
 moderate moderate moderate moderate weak
DNAJB1–PRKACA
(HGNC:5270, HGNC:9380)
MONDO:0006210
(MONDO:0006210)
 strong moderate moderate strong weak
HIP1–ALK
(HGNC:4913, HGNC:427)
lung adenocarcinoma
(MONDO_0005061)
 strong strong moderate strong weak
HOXD13–NUP98
(HGNC:5136, HGNC:8068)
MONDO:0018871
(MONDO:0018871)
 strong moderate strong strong weak
HOXC13–NUP98
(HGNC:5125, HGNC:8068)
MONDO:0018874
(MONDO:0018874)
 moderate weak moderate strong weak
HOXC11–NUP98
(HGNC:5123, HGNC:8068)
MONDO:0018874
(MONDO:0018874)
 moderate weak weak moderate weak
HMGA2–NFIB
(HGNC:5009, HGNC:7785)
lipoma
(MONDO_0005106)
 strong weak weak strong weak
HMGA2–RAD51B
(HGNC:5009, HGNC:9822)
uterine corpus leiomyoma
(MONDO_0007886)
 moderate weak weak moderate weak
DUX4–IGH
(HGNC:50800, HGNC:5477)
MONDO:0000870
(MONDO:0000870)
 strong weak moderate strong weak
HOXA9–NUP98
(HGNC:5109, HGNC:8068)
myeloid leukemia
(MONDO_0004643)
 strong moderate strong strong moderate
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