Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
HMGA2–NCOR2
(HGNC:5009, HGNC:7673)
lipoma
(MONDO_0005106)
 strong moderate moderate strong weak
HMGA2–PLAG1
(HGNC:5009, HGNC:9045)
MONDO:0016611
(MONDO:0016611)
 weak weak weak weak weak
HMGA2–LPP
(HGNC:5009, HGNC:6679)
MONDO:0005106
(MONDO:0005106)
 strong weak moderate strong weak
HLA-DRB1–MET
(HGNC:4948, HGNC:7029)
lung neoplasm
(MONDO_0021117)
 moderate moderate weak moderate weak
HMGA2–HMGA1
(HGNC:5009, HGNC:5010)
weak weak weak weak weak
HEY1–NCOA2
(HGNC:4880, HGNC:7669)
MONDO:0006853
(MONDO:0006853)
 strong strong moderate strong weak
ANK3–RET
(HGNC:494, HGNC:9967)
MONDO:0005575
(MONDO:0005575)
 moderate moderate moderate moderate weak
HJV–BCL2
(HGNC:4887, HGNC:990)
MONDO:0018906
(MONDO:0018906)
 weak weak weak weak weak
CFH–CFHR1
(HGNC:4883, HGNC:4888)
MONDO:0016244
(MONDO:0016244)
 strong weak moderate strong weak
HBB–HBD
(HGNC:4827, HGNC:4829)
MONDO:0000984
(MONDO:0000984)
 weak weak weak weak weak
ALK–RANBP2
(HGNC:427, HGNC:9848)
liver inflammatory myofibroblastic tumor
(MONDO_0004726)
 strong strong moderate strong weak
HAS2–PLAG1
(HGNC:4819, HGNC:9045)
MONDO:0016611
(MONDO:0016611)
 strong weak moderate strong weak
GPR34–IGH
(HGNC:4490, HGNC:5477)
MALT lymphoma
(MONDO_0007650)
 strong moderate weak strong weak
ALK–RET
(HGNC:427, HGNC:9967)
non-small cell lung carcinoma
(MONDO_0005233)
 weak weak weak weak weak
GLI1–PTCH1
(HGNC:4317, HGNC:9585)
mesenchymal cell neoplasm
(MONDO_0002616)
 moderate weak moderate strong weak
GLI1–FOXO4
(HGNC:4317, HGNC:7139)
mesenchymal cell neoplasm
(MONDO_0002616)
 strong weak moderate strong weak
ALK–PPP1CB
(HGNC:427, HGNC:9282)
MONDO:0016262
(MONDO:0016262)
 strong strong moderate strong weak
ALK–NTRK1
(HGNC:427, HGNC:8031)
MONDO:0004970
(MONDO:0004970)
 weak weak weak weak weak
A2M–ALK
(HGNC:7, HGNC:427)
fetal lung interstitial tumor
(MONDO_0017289)
 strong strong moderate strong weak
EWSR1–NFATC2
(HGNC:3508, HGNC:7776)
MONDO:0005164
(MONDO:0005164)
 strong moderate moderate strong weak
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