Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
ALK–ATIC
(HGNC:427, HGNC:794)
MONDO:0006112
(MONDO:0006112)
 strong strong moderate strong weak
ALK–NPM1
(HGNC:427, HGNC:7910)
MONDO:0009348
(MONDO:0009348)
 strong strong moderate strong weak
EWSR1–SMAD3
(HGNC:3508, HGNC:6769)
spindle cell neoplasm
(MONDO_0020664)
 strong weak moderate strong weak
EWSR1–FLII
(HGNC:3508, HGNC:3750)
MONDO:0012817
(MONDO:0012817)
 weak weak weak weak weak
ALK–MSN
(HGNC:427, HGNC:7373)
MONDO:0020325
(MONDO:0020325)
 moderate moderate weak strong weak
ETV6–MN1
(HGNC:3495, HGNC:7180)
acute lymphoblastic leukemia
(MONDO_0004967)
 strong strong strong moderate weak
SERPINE1–FOSB
(HGNC:8583, HGNC:3797)
MONDO:0004187
(MONDO:0004187)
 strong strong moderate strong weak
FOXO1–PAX7
(HGNC:3819, HGNC:8621)
alveolar rhabdomyosarcoma
(MONDO_0009994)
 strong moderate moderate strong weak
ALK–KLC1
(HGNC:427, HGNC:6387)
MONDO:1040026
(MONDO:1040026)
 strong strong moderate moderate strong
GAB1–ABL1
(HGNC:4066, HGNC:76)
soft tissue neoplasm
(MONDO_0006424)
 moderate weak weak moderate weak
FOXO1–PAX3
(HGNC:3819, HGNC:8617)
MONDO:0009994
(MONDO:0009994)
 strong moderate strong strong moderate
FN1–ALK
(HGNC:3778, HGNC:427)
MONDO:0024621
(MONDO:0024621)
 strong strong moderate moderate weak
GATA6–FOXO1
(HGNC:4174, HGNC:3819)
MONDO:0021169
(MONDO:0021169)
 moderate weak moderate strong weak
FOXP1–IGH
(HGNC:3823, HGNC:5477)
MONDO:0018905
(MONDO:0018905)
 strong moderate moderate strong weak
FOXO3–KMT2A
(HGNC:3821, HGNC:7132)
therapy related acute myeloid leukemia and myelodysplastic syndrome
(MONDO_0019457)
 strong weak moderate moderate weak
FLT3–PML
(HGNC:3765, HGNC:9113)
MONDO:0012883
(MONDO:0012883)
 weak weak weak weak weak
FN1–KMT2A
(HGNC:3778, HGNC:7132)
MONDO:0010643
(MONDO:0010643)
 weak weak weak weak weak
FOS–FOSB
(HGNC:3796, HGNC:3797)
epithelioid hemangioma
(MONDO_0021169)
 strong weak moderate strong weak
FGFR2–NRG1
(HGNC:3689, HGNC:7997)
MONDO:0019087
(MONDO:0019087)
 strong strong moderate strong weak
FGFR2–FGFR3
(HGNC:3689, HGNC:3690)
MONDO:0002108
(MONDO:0002108)
 weak weak weak weak weak
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