Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
FGFR3–IGH
(HGNC:3690, HGNC:5477)
plasma cell myeloma
(MONDO_0009693)
 strong moderate strong moderate weak
FGFR1–FN1
(HGNC:3688, HGNC:3778)
MONDO:0018124
(MONDO:0018124)
 strong strong moderate strong weak
FN1–FGFR2
(HGNC:3778, HGNC:3689)
strong moderate moderate strong weak
FGFR1–RET
(HGNC:3688, HGNC:9967)
thyroid gland papillary carcinoma
(MONDO_0005075)
 weak weak weak weak weak
FGFR1–PLAG1
(HGNC:3688, HGNC:9045)
strong weak weak moderate weak
EWSR1–POU5F1
(HGNC:3508, HGNC:9221)
MONDO:0005102
(MONDO:0005102)
 strong moderate moderate moderate weak
FGFR1–FGFR3
(HGNC:3688, HGNC:3690)
MONDO:0009693
(MONDO:0009693)
 moderate moderate moderate moderate weak
FGF13–MCF2
(HGNC:3670, HGNC:6940)
weak weak weak weak weak
EWSR1–PLAGL1
(HGNC:3508, HGNC:9046)
MONDO:0021193
(MONDO:0021193)
 weak weak weak weak weak
EWSR1–NR4A3
(HGNC:3508, HGNC:7982)
MONDO:0012825
(MONDO:0012825)
 strong strong moderate strong weak
EWSR1–GDNF
(HGNC:3508, HGNC:4232)
clear cell sarcoma
(MONDO_0002926)
 weak weak weak weak weak
EWSR1–PBX3
(HGNC:3508, HGNC:8634)
MONDO:0003158
(MONDO:0003158)
 strong moderate moderate strong weak
EWSR1–PBX1
(HGNC:3508, HGNC:8632)
myoepithelial tumor
(MONDO_0002380)
 moderate weak weak moderate weak
EWSR1–NFATC1
(HGNC:3508, HGNC:7775)
MONDO:0006500
(MONDO:0006500)
 weak weak weak moderate weak
EWSR1–MYB
(HGNC:3508, HGNC:7545)
MONDO:0044903
(MONDO:0044903)
 moderate weak moderate moderate weak
ETV6–PDGFRA
(HGNC:3495, HGNC:8803)
MONDO:0018881
(MONDO:0018881)
 moderate moderate moderate strong weak
ETV6–PAX5
(HGNC:3495, HGNC:8619)
MONDO:0004967
(MONDO:0004967)
 strong strong moderate strong weak
MECOM–PSMD2
(HGNC:3498, HGNC:9559)
acute myeloid leukemia
(MONDO_0018874)
 weak weak weak weak weak
MECOM–GATA2
(HGNC:3498, HGNC:4171)
MONDO:0018874
(MONDO:0018874)
 strong moderate strong strong weak
ETV6–ABL2
(HGNC:3495, HGNC:77)
acute myeloid leukemia
(MONDO_0018874)
 strong weak moderate moderate weak
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