Fusions

Summaries of gene fusions and their clinical relevance.

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Fusion Disease Driver/Marker Power Therapeutic Actionability Prognostic Impact Diagnostic Specificity Monitoring Utility Actions
ERG–FUS
(HGNC:3446, HGNC:4010)
acute myeloid leukemia
(MONDO_0018874)
 strong strong strong strong moderate
AHCYL1–FGFR2
(HGNC:344, HGNC:3689)
biliary tract cancer
(MONDO_0003060)
 moderate strong weak moderate weak
KMT2A–FRYL
(HGNC:7132, HGNC:29127)
leukemia
(MONDO_0005059)
 moderate weak weak moderate weak
ERG–FLI1
(HGNC:3446, HGNC:3749)
weak weak weak weak weak
ERG–EWSR1
(HGNC:3446, HGNC:3508)
MONDO:0012817
(MONDO:0012817)
 strong weak moderate strong moderate
ERG–ETV1
(HGNC:3446, HGNC:3490)
MONDO:0008315
(MONDO:0008315)
 moderate strong strong moderate weak
EBF1–PDGFRB
(HGNC:3126, HGNC:8804)
T-cell acute lymphoblastic leukemia
(MONDO_0004963)
 moderate moderate strong moderate weak
EPS15–KMT2A
(HGNC:3419, HGNC:7132)
MONDO:0012883
(MONDO:0012883)
 moderate weak moderate moderate weak
ACOD1–ALK
(HGNC:33904, HGNC:427)
colorectal carcinoma
(MONDO_0024331)
 weak weak weak weak weak
ELN–PAX5
(HGNC:3327, HGNC:8619)
B-cell acute lymphoblastic leukemia
(MONDO_0004947)
 strong weak moderate strong weak
ELK4–SLC45A3
(HGNC:3326, HGNC:8642)
MONDO:0008315
(MONDO:0008315)
 strong moderate strong strong weak
EGFR–RAD51
(HGNC:3236, HGNC:9817)
MONDO:0008903
(MONDO:0008903)
 strong strong moderate strong weak
EGFR–ALK
(HGNC:3236, HGNC:427)
MONDO:0005233
(MONDO:0005233)
 weak weak weak weak weak
EGFR–VOPP1
(HGNC:3236, HGNC:34518)
MONDO:0005061
(MONDO:0005061)
 moderate weak moderate moderate weak
NUTM1–MXI1
(HGNC:29919, HGNC:7534)
nut midline carcinoma
(MONDO_0005563)
 weak weak weak moderate weak
EGFR–SEPTIN14
(HGNC:3236, HGNC:33280)
colorectal cancer
(MONDO_0005575)
 strong strong moderate moderate weak
SPECC1L–NTRK3
(HGNC:29022, HGNC:8033)
sarcoma of cervix uteri
(MONDO_0016280)
 strong strong moderate strong weak
PLEKHH2–ALK
(HGNC:30506, HGNC:427)
MONDO:0005061
(MONDO:0005061)
 strong strong moderate strong weak
TBL1XR1–PML
(HGNC:29529, HGNC:9113)
MONDO:0012883
(MONDO:0012883)
 weak weak weak weak weak
MYO18A–PDGFRB
(HGNC:31104, HGNC:8804)
strong strong moderate strong weak
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